Jason E Gestwicki Selected Research

HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)

1/2022	Analogs of the Heat Shock Protein 70 Inhibitor MKT-077 Suppress Medullary Thyroid Carcinoma Cells.
1/2022	Selective vulnerabilities in the proteostasis network of castration-resistant prostate cancer.
1/2021	Inhibitors of heat shock protein 70 (Hsp70) with enhanced metabolic stability reduce tau levels.
1/2020	Neutral analogs of the heat shock protein 70 (Hsp70) inhibitor, JG-98.
7/2018	Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70).
1/2018	X-linked inhibitor of apoptosis protein (XIAP) is a client of heat shock protein 70 (Hsp70) and a biomarker of its inhibition.
4/2016	Allosteric heat shock protein 70 inhibitors block hepatitis C virus assembly.
1/2016	Combined chemical-genetic approach identifies cytosolic HSP70 dependence in rhabdomyosarcoma.
11/2013	Analogs of the Allosteric Heat Shock Protein 70 (Hsp70) Inhibitor, MKT-077, as Anti-Cancer Agents.
6/2013	Synthesis and initial evaluation of YM-08, a blood-brain barrier permeable derivative of the heat shock protein 70 (Hsp70) inhibitor MKT-077, which reduces tau levels.

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Jason E Gestwicki Research Topics

Disease

20	Neoplasms (Cancer) 10/2020 - 01/2008
18	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2021 - 10/2004
17	Alzheimer Disease (Alzheimer's Disease) 12/2019 - 10/2004
14	Tauopathies 01/2021 - 09/2009
8	Breast Neoplasms (Breast Cancer) 01/2019 - 01/2010
5	Prostatic Neoplasms (Prostate Cancer) 01/2022 - 01/2018
4	Parkinson Disease (Parkinson's Disease) 01/2021 - 04/2012
4	X-Linked Bulbo-Spinal Atrophy 01/2015 - 05/2010
3	Infections 01/2022 - 11/2012
3	Frontotemporal Dementia (Semantic Dementia) 12/2019 - 04/2012
3	Huntington Disease (Huntington's Disease) 01/2015 - 04/2014
2	Cataract (Cataracts) 01/2019 - 11/2015
2	Disease Progression 11/2018 - 01/2015
2	Proteostasis Deficiencies 11/2016 - 11/2014
2	Gaucher Disease (Gaucher's Disease) 08/2014 - 05/2006
2	Dementia (Dementias) 07/2012 - 11/2010
1	Thyroid Neoplasms (Thyroid Cancer) 01/2022
1	Synucleinopathies 01/2021
1	Colonic Neoplasms (Colon Cancer) 01/2020
1	Inborn Genetic Diseases (Disease, Hereditary) 01/2020
1	Adenocarcinoma 01/2020
1	Limb-Girdle Muscular Dystrophies (Limb-Girdle Muscular Dystrophy) 01/2020
1	Neoplasm Metastasis (Metastasis) 01/2019
1	Legionnaires' Disease (Legionnaire's Disease) 01/2019
1	Muscular Diseases (Myopathy) 12/2018
1	Glioblastoma (Glioblastoma Multiforme) 01/2018
1	Hypertrophic Cardiomyopathy (Hypertrophic Obstructive Cardiomyopathy) 01/2018
1	Mental Disorders (Mental Disorder) 11/2016
1	Machado-Joseph Disease (Spinocerebellar Ataxia Type 3) 11/2016
1	Hepatitis C 04/2016
1	Rhabdomyosarcoma 01/2016
1	Dehydration (Water Stress) 04/2015
1	Animal Disease Models 01/2015

Drug/Important Bio-Agent (IBA)

25	Proteins (Proteins, Gene)FDA Link 10/2020 - 10/2004
12	HSP70 Heat-Shock Proteins (Heat-Shock Protein 70)IBA 01/2022 - 11/2006
12	Molecular Chaperones (Chaperone, Molecular)IBA 01/2022 - 11/2006
10	Pharmaceutical PreparationsIBA 01/2022 - 01/2010
8	polyglutamineIBA 11/2016 - 05/2010
6	Microtubule-Associated Proteins (Microtubule-Associated Protein 2)IBA 01/2021 - 09/2011
6	Peptides (Polypeptides)IBA 10/2020 - 11/2006
5	Androgen Receptors (Androgen Receptor)IBA 01/2020 - 05/2010
4	MKT 077IBA 01/2022 - 01/2012
4	Amyloid beta-PeptidesIBA 12/2010 - 11/2006
3	Carrier Proteins (Binding Protein)IBA 01/2021 - 04/2012
3	Heat-Shock Proteins (Heat-Shock Protein)IBA 10/2020 - 11/2014
3	glucose-regulated proteinsIBA 10/2020 - 01/2020
3	Methylene Blue (Methylthioninium Chloride)FDA Link 04/2012 - 05/2010
2	SynucleinsIBA 01/2021 - 01/2015
2	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 10/2020 - 01/2020
2	mortalinIBA 10/2020 - 01/2020
2	Phosphotransferases (Kinase)IBA 10/2020 - 01/2019
2	benzothiazoleIBA 01/2020 - 07/2018
2	Crystallins (Crystallin)IBA 01/2019 - 11/2015
2	Therapeutic UsesIBA 01/2019 - 11/2006
2	Protein Isoforms (Isoforms)IBA 01/2018 - 05/2015
2	N-(3-pyridylmethyl)adriamycin (YM 1)IBA 09/2014 - 01/2012
2	EnzymesIBA 08/2014 - 05/2006
2	Glucosylceramidase (Glucocerebrosidase)IBA 08/2014 - 05/2006
2	rhodacyanineIBA 11/2013 - 01/2012
2	Adenosine Triphosphatases (ATPase)IBA 01/2010 - 09/2009
1	Proteasome Endopeptidase Complex (Proteasome)IBA 10/2021
1	MAP Kinase Kinase Kinases (MAP Kinase Kinase Kinase)IBA 10/2020
1	Glucose (Dextrose)FDA LinkGeneric 10/2020
1	Lysine AcetyltransferasesIBA 01/2020
1	CholesterolIBA 01/2020
1	Firefly LuciferasesIBA 01/2020
1	BenzothiazolesIBA 01/2020
1	pyridineIBA 01/2020
1	OxysterolsIBA 01/2019
1	CytokinesIBA 01/2019
1	VP1-001IBA 01/2019
1	Bacterial Proteins (Bacterial Protein)IBA 01/2019
1	Phenobarbital (Luminal)FDA Link 01/2019
1	CaspasesIBA 01/2019
1	Proline (L-Proline)FDA Link 12/2018
1	Isoleucine (L-Isoleucine)FDA Link 12/2018
1	Valine (L-Valine)FDA Link 12/2018
1	Small Heat-Shock ProteinsIBA 12/2018
1	Lysine (L-Lysine)FDA Link 11/2018
1	Sirtuin 1IBA 11/2018
1	NucleotidesIBA 07/2018
1	LigandsIBA 01/2018
1	Inosine Diphosphate (IDP)IBA 01/2018
1	benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketoneIBA 01/2018
1	Androgen Antagonists (Antiandrogens)IBA 01/2018
1	Cardiac MyosinsIBA 01/2018
1	X-Linked Inhibitor of Apoptosis ProteinIBA 01/2018
1	KHS101IBA 01/2018
1	Peptidylprolyl Isomerase (Prolyl Isomerase)IBA 11/2016
1	Aripiprazole (Abilify)FDA Link 11/2016
1	Viral Nonstructural ProteinsIBA 04/2016
1	human ERBB2 proteinIBA 01/2016
1	Biomarkers (Surrogate Marker)IBA 01/2016
1	AcidsIBA 04/2015

Therapy/Procedure

9	Therapeutics 01/2018 - 10/2004
2	Castration 01/2022 - 01/2018
1	Role Playing (Playing, Role) 01/2019
1	Topical Administration 01/2019
1	Lenses 01/2019
1	Drug Therapy (Chemotherapy) 01/2016